IX. the Comparative Activity in Vivo of Trypsin and Aspergillin O (Mold Fibrinolysin)

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Abstract
The activity of Aspergillin O (mold fibrinolysin) was compared to that of trypsin in vivo in dogs. At low doses (2 to 5 mgs/kilo weight of trypsin or equivalent amounts of Aspergillin O) both substances accelerated moderately the clotting time of recalcified plasma in glass and in silicone-coated test tubes and the generation of thrombin, without exhibiting important fibrinolytic effects. In high doses (10 to 20 mg/kilo weight trypsin or equivalent amounts of Aspergillin O) the two agents showed striking differences in activity. Both exhibited strong fibrinolytic activity. Trypsin, however, caused temporary incoagulability of the blood, whereas it accelerated the generation of thrombin. On the other hand, Aspergillin O delayed the formation of thrombin and induced less severe hypocaogulability of the blood. At least under these experimental conditions, Aspergillin O induced adequate fibrinolysis with less intense and more promptly reversible effects than trypsin.