EFFECTS OF SURUGATOXIN ON ADRENERGIC ALLYINNERVATED TISSUES

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Abstract
Effects of surugatoxin (SGTX, isolated from Babylonia japonica), a new ganglionic blocking agent, on adrenergically innervated tissues; guinea pig isolated atria and vas deferens were investigated. SGTX (1, 10 .mu.M) reduced the cardiostimulatory response of the atria to nicotine and partially reduced the response to 1,1-dimethyl-4-phenylpiperazinium (DMPP) and 5-hydroxytryptamine without affecting responses to noradrenaline [norepinephrine], tyramine and histamine. The contractile response of the vas deferens to nicotine, DMPP and hypogastric nerve stimulation was markedly reduced by SGTX (1, 10 .mu.M); that to noradrenaline, acetylcholine and transmural stimulation was not affected. Apparently SGTX has an antagonistic action on nicotinic receptors in these tissues, in sympathetic ganglia and in guinea pig ileum.