The effect of adenine on platelet storage

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Abstract
Adenine was an approved additive to citrate-phosphate-dextrose anticoagulant for whole blood collection and extended the storage life of red blood cells. In vitro methods were used to investigate the effects of adenine on platelet function and viability durng 72 h of storage at 22.degree. C. Although the hypotonic shock response and aggregation were decreased, these effects were reversed following separation and resuspension in fresh adenine-free plasma. Serotonn uptake and release were not affected by adenine; however, malonaldehyde formation was slightly enhanced. Glucose, pH and pO2 [partial pressure] levels were lower and lactate levels were slightly higher than in platelets stored without adenine. There was apparently little in vitro effect of adenine on platelets stored as platelet-rich plasma or platelet concentrate.