Ataxia–Telangiectasia: An Important Clue

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Abstract
The paper by Carbonari et al. in this issue of the Journal calls attention to the rapidly expanding knowledge of the molecular processes underlying ataxia—telangiectasia.1 Previous observations provided a description of the major distinctive immunologic and histologic abnormalities in this disease and pointed out the high incidence of associated lymphocytic cancers.2 , 3 More recent studies of patients with ataxia—telangiectasia have taken advantage of new techniques and information and have moved to the molecular level. The observations of Carbonari et al., an example of molecular-level studies, bring new insight into an important step in lymphocyte differentiation.Carbonari and his colleagues report that . . .