Cytotoxic Alkaloids from the Marine SpongeThorectandrasp.
- 1 June 2004
- journal article
- research article
- Published by Taylor & Francis in Natural Product Research
- Vol. 18 (3) , 225-229
- https://doi.org/10.1080/14786410310001622077
Abstract
Three β-carboline alkaloids, Compound 1, 1-deoxysecofascaplysin A (2), and fascaplysin (3), were isolated from the aqueous and organic extracts of the marine sponge Thorectandra sp. The structures of 1 and 2 were determined on the basis of spectral data. Compound 1 inhibited the growth of MCF-7 (breast) with an IC50 of 5.9 µg/mL while Compound 2 inhibited the growth of MCF-7 as well as OVCAR-3 (ovarian) human tumor cell lines with IC50s of 1.5 and 2.2 µg/mL, respectively.Keywords
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