In Vitro Activities of New Antifungal Agents against Chaetomium spp. and Inoculum Standardization
Open Access
- 1 October 2003
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (10) , 3161-3164
- https://doi.org/10.1128/aac.47.10.3161-3164.2003
Abstract
Chaetomium is an unusual etiological agent of human infections, but the mortality rate among immunocompromised patients is considerably greater than that among nonimmunocompromised individuals. We investigated the in vitro antifungal susceptibilities to novel antifungal agents of 19 strains belonging to three species of Chaetomium which have been involved in human infections, i.e., Chaetomium globosum , C. atrobrunneum , and C. nigricolor , and one strain of the closely related species Achaetomium strumarium . A modification of the NCCLS reference microdilution method (M38-A) was used to evaluate the in vitro activities of ravuconazole, voriconazole, albaconazole, and micafungin. Micafungin was not active at all, while the geometric mean MICs and minimum effective concentrations of the three triazoles were less than 0.5 and 0.4 μg/ml, respectively.Keywords
This publication has 12 references indexed in Scilit:
- In Vitro Synergy of Caspofungin and Itraconazole against Aspergillus spp.: MIC versus Minimal Effective Concentration End PointsAntimicrobial Agents and Chemotherapy, 2003
- Evaluation of Broth Microdilution Testing Parameters and Agar Diffusion Etest Procedure for Testing Susceptibilities of Aspergillus spp. to Caspofungin Acetate (MK-0991)Journal of Clinical Microbiology, 2003
- In Vitro Synergy of Caspofungin and Amphotericin B against Aspergillus and Fusarium sppAntimicrobial Agents and Chemotherapy, 2002
- In Vitro Antifungal Activities of the New Triazole UR-9825 against Clinically Important Filamentous FungiAntimicrobial Agents and Chemotherapy, 2001
- Correlation between Antifungal Susceptibilities of Coccidioides immitis In Vitro and Antifungal Treatment with Caspofungin in a Mouse ModelAntimicrobial Agents and Chemotherapy, 2001
- Inoculum Standardization for Antifungal Susceptibility Testing of Filamentous Fungi Pathogenic for HumansJournal of Clinical Microbiology, 2001
- In Vitro Susceptibility Testing Methods for Caspofungin against Aspergillus and Fusarium IsolatesAntimicrobial Agents and Chemotherapy, 2001
- Inoculum preparation for in-vitro susceptibility testing of filamentous fungi.Journal of Antimicrobial Chemotherapy, 1998
- Pathogenicity and antifungal susceptibility ofChaetomium speciesEuropean Journal of Clinical Microbiology & Infectious Diseases, 1995
- Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-D-glucan synthaseAntimicrobial Agents and Chemotherapy, 1994