Inhibition of mitochondrial respiration by analogs of 4-phenylpyridine and 1-methyl-4-phenylpyridinium cation (MPP+), the neurotoxic metabolite of MPTP
- 26 October 1987
- journal article
- research article
- Published by Elsevier in Biochemical and Biophysical Research Communications
- Vol. 148 (2) , 684-693
- https://doi.org/10.1016/0006-291x(87)90931-4
Abstract
No abstract availableThis publication has 71 references indexed in Scilit:
- Model study on the bioreduction of paraquat, MPP+, and analogs. Evidence against a “redox cycling” mechanism in MPTP neurotoxicityBiochemical and Biophysical Research Communications, 1987
- Characterization of the Binding of N‐Methyl‐4‐Phenylpyridine, the Toxic Metabolite of the Parkinsonian Neurotoxin N‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine, to NeuromelaninJournal of Neurochemistry, 1987
- Biochemistry of the neurotoxic action of MPTP: or how a faulty batch of ‘designer drug’ led to parkinsonism in drug abusersTrends in Biochemical Sciences, 1987
- The pharmacology of the parkinsonian syndrome producing neurotoxin MPTP (1–methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine) and structurally related compoundsMedicinal Research Reviews, 1986
- Comparative toxicity of MPTP, MPP+ and 3,3-dimethyl-MPDP+ to dopaminergic neurons of the rat substantia nigraEuropean Journal of Pharmacology, 1986
- Mechanism of induction of Parkinson's disease by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Chemical and electrochemical characterization of a geminal-dimethyl-blocked analog of a postulated toxic metaboliteJournal of the American Chemical Society, 1986
- 1-Methyl-4-phenylpyridine is neurotoxic to the nigrostriatal dopamine pathwayNature, 1986
- Dopaminergic toxicity after the stereotaxic administration of the 1-methyl-4-phenylpyridinium ion (MPP+) to ratsNeuroscience Letters, 1985
- IV. Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effectsLife Sciences, 1985
- MPTP and parkinson's diseaseTrends in Neurosciences, 1985