Some Dietary Influences on the Excretion and Biological Activity of an Anorexigenic Substance in the Urine of Rats

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Abstract
An investigation was made of the effects of diet composition, spaced feedings and amount of food consumed, upon the rate of excretion and biological activity of FMS 1A, a natural anorexigenic substance extracted from urine. The amounts and total anorexigenic activity of FMS 1A excreted by adult male rats were greatest when diets were fed which contained a high proportion of protein (50% casein by weight). Rats restricted to one daily 2-hour feeding in the morning tended to excrete a higher proportion of their daily anorexigenic activity in the daytime and excreted only half as much FMS 1A as those allowed free access to food 24 hours per day. The amounts and total activity of FMS 1A excreted in the urine were found to be directly proportional to the amounts of food consumed. Anorexigenic activity was determined by means of an in vivo bioassay using young male rats. In additional experiments, the effects of injections of a stock preparation of FMS 1A upon rats restricted to one daily feeding or consuming different amounts of food were observed. A possible role of FMS 1A in the physiological control of food intake is discussed in the light of the data obtained in these and previously reported experiments.
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