EFFECT OF dl-α-TOCOPHEROL ACETATE ON PROGESTERONE METABOLISM
- 1 November 1948
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 8 (11) , 982-992
- https://doi.org/10.1210/jcem-8-11-982
Abstract
In 10 postmenopausal women, the excretion of urinary pregnanediol after injn. of progesterone was increased by DL-alpha-tocopherol acetate treatment. The effect was statistically highly significant. The result is interpreted as a shift in progesterone metabolism in favor of pregnanediol production, provoked by the antioxidative effect of alpha-tocopherol. A method is described for the detn. of as little as 0.2-0.8 mg. of pregnanediol in 100 or 1000 cc. of urine. Up to 30 detns. a week can be made by 2 persons.Keywords
This publication has 7 references indexed in Scilit:
- The separation of non-ketonic and ketonic sodium glucuronidates from the ‘sodium pregnanediol glucuronidate’ of human pregnancy urine: the isolation of pure sodium pregnane-3(α), 20(α)-diol glucuronidateBiochemical Journal, 1947
- Determination of pregnanediol in urine for diagnostic purposesBiochemical Journal, 1947
- Die fluorometrische Methode zur Bestimmung von Tocopherol. 3. MitteilungHelvetica Chimica Acta, 1945
- THE SITE OF METABOLISM OF PROGESTERONE IN THE RABBITAmerican Journal of Physiology-Legacy Content, 1944
- The Excretion of Sodium Pregnanediol Glucuronidate in the Urine Following the Oral Administration of Anhydro-Hydroxy-Progesterone and Progesterone to Patients with Secondary Amenorrhea1Journal of Clinical Endocrinology & Metabolism, 1944
- Die fluorometrische Methode zur Bestimmung von Tocopherol. 2. Mitteilung. Die Bestimmung im Serum, in Milch, tierischen und pflanzlichen FettenHelvetica Chimica Acta, 1943
- The Excretion of Estrogen and Pregnanediol Preceding Normal Parturition**Read by invitation, at the Sixty-Sixth Annual Meeting of the American Gynecological Society, Colorado Springs, Colo., May 26 to 28, 1941.American Journal of Obstetrics and Gynecology, 1941