Albumin Content of Rat Hepatic Cells at Different Levels of Protein Intake

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Abstract
A study was carried out to determine whether the protein content of the diet affects serum albumin synthesis by regulating the number of liver cells actively making albumin. A fluorescent anti-serum was prepared against rat albumin and used for identification of liver cells containing albumin. The number of albumin-containing cells in the liver was greatest when animals were fed a diet rich in protein; the number was at an intermediate level when maintained with a stock diet; and the number was very infrequent when the diet was devoid of protein. This observation is consistent with the effects of feeding different levels of protein on serum albumin turnover, on the protein content of the liver, and on the distribution of albumin in the liver cell.
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