Variations in glycerol kinetics in Reye's syndrome

Publisher Website
Google Scholar
Abstract
Glycerol kinetics and adverse effects were studied in 9 patients with Reye''s syndrome. Glycerol was given by continuous infusion over 2 h, half over the first 0.5 h and the remainder over the next 1.5 h. The dose was adjusted to keep intracranial pressure .ltoreq. 15 mmHg. At steady state, serial blood samples were collected during glycerol infusion and analyzed by an enzymatic assay specific for glycerol. At 0.75-1.75 g/kg per 2 h glycerol doses, the serum levels ranged from 1.48-5.83 mg/ml. Total body clearance ranged from 1.99-5.1 ml/kg per min. Glycerol clearance was not related to serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), or serum ammonia levels. Glycerol provided effective control of intracranial pressure in all patients. Temporary elevation of serum creatinine and blood urea nitrogen (BUN) and presence of hemolysis in 2 patients appeared to be related to glycerol.