Effect of Alloxan on Feed Consumption and on Replacement Therapy With Graded Levels of Insulin in Rats.

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Abstract
Summary Alloxan diabetes was induced in a group of 18 female Sprague-Dawley-Rolfsmeyer rats weighing a mean of 237 g. Prior to treatment they consumed a mean of 13.07 g/day and 5.18 g/100 g BW. Following treatment they consumed a mean of 22.13 g/day and 9.46 g/100 g BW of Purina Lab. Chow daily during a 10-day period, an increase of 69%/day and 83%/100 g BW. Graded levels of insulin (1 to 4 u) were administered during 6-day periods. On 2 u/day, feed consumption decreased 9% (non-significant), on 3 u 20% (significant) and at 4 u a highly significant decrease of 23%/100 g BW was observed. At the 3 and 4 u level, 2 and 5 rats died.