Further Observations on the Occurrence of the Thyrotropin Inhibitor in Urine
- 1 August 1962
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 22 (8) , 800-806
- https://doi.org/10.1210/jcem-22-8-800
Abstract
The investigation of factors affecting thyrotropin inhibitor (TSH-I) in urine of patients and euthyroid individuals has been continued. A modified procedure for chick thyroidal radioiodine release for the bio-assay of TSH and a benzoic acid concentration procedure of TSH-I of urine is described. TSH-I preparations from 5-day urine collections revealed minimal presence of TSH-I only in 3 of 10 untreated hypothyroid patients, while the administration of Na-L- or Na-D-thyroxine to euthyroid subjects, hypothyroid and hyperthyroid patients, or radioiodine treatment in hyperthyroid patients invariably resulted in increasing titers of TSH-I. The rise in TSH-I could be correlated with elevation of serum proteinbound iodine levels and reduction of serum cholesterol levels, usually occurring during the first 3 weeks following increase of the medication dose. The increased TSH-I titer reached a peak, followed by a period of adjustment and, in most cases, by a decrease of TSH-I thereafter.Keywords
This publication has 11 references indexed in Scilit:
- THE EFFECT OF PURIFIED BOVINE THYROIDSTIMULATING HORMONE IN MAN. II. LOSS OF EFFECTIVENESS WITH PROLONGED ADMINISTRATION*Journal of Clinical Endocrinology & Metabolism, 1961
- Effects of Antiserum in Bloassay of Thyrotropin and Thyroid Activator of HyperthyroidismExperimental Biology and Medicine, 1960
- INHIBITION OF THYROTROPIC ACTIVITY BY IMMUNOLOGICALLY SPECIFIC ANTISERUM11Endocrinology, 1960
- LIMITATIONS OF THE CHICK RADIOPHOSPHORUS UPTAKE ASSAY AND THE CHICK RADIOIODINE DEPLETION ASSAY FOR THYROTROPIC HORMONE WHEN APPLIED TO BLOOD AND URINE12Endocrinology, 1959
- THE PRESENCE OF AN INHIBITOR OF THYROTROPIN IN HUMAN URINE*†Journal of Clinical Endocrinology & Metabolism, 1958
- AN IMPROVED ASSAY METHOD FOR THYROTROPHIN USING DEPLETION OF I131FROM THE THYROID OF DAY-OLD CHICKSEndocrinology, 1957
- AN IMPROVED BIOASSAY METHOD FOR THYROTROPIC HORMONE USING THYROID UPTAKE OF RADIOPHOSPHORUS12Endocrinology, 1956
- ZONE ELECTROPHORESIS IN THE PREPARATION OF SERUM AND PITUITARY EXTRACTS FOR BIOASSAY OF THYROID STIMULATING HORMONE1Endocrinology, 1956
- HYPERPLASIA AND I131UPTAKE OF THE GUINEA PIG THYROID DURING AND AFTER CHRONIC PROPYLTHIOURACIL TREATMENT*Endocrinology, 1951
- THE CLINICAL DETERMINATION OF PROTEIN-BOUND IODINE 1Journal of Clinical Investigation, 1951