The mitochondrial permeability transition
- 1 January 1998
- journal article
- review article
- Published by Wiley in BioFactors
- Vol. 8 (3-4) , 273-281
- https://doi.org/10.1002/biof.5520080315
Abstract
This review summarizes recent work on the regulation of the permeability transition pore, a cyclosporin A‐sensitive mitochondrial channel that may play a role in intracellular calcium homeostasis and in a variety of forms of cell death. The basic bioenergetics aspects of pore modulation are discussed, with some emphasis on the links between oxidative stress and pore dysregulation as a potential cause of mitochondrial dysfunction that may be relevant to cell injury.Keywords
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