The Difference in Effect of Predosing with Antiallergic Compounds between the Rat PCA Model and the Monkey Asthma Model

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Abstract
DSCG [disodium chromoglycate] and PRD-92-Ea showed tachyphylaxis in the rat PCA [passive cutaneous anaphylaxis] test when a large i.v. dose (40 mg/kg of DSCG and 20 mg/kg of PRD-92-Ea) was given 30 min before administering i.v. the expected effective doses at the time of antigen challenge. This predosing led to a marked loss of effectiveness. Cross-reacting tachyphylaxis was also demonstrated in this model. Predosing rats with DSCG led to a great loss of effectiveness of a subsequent expected active dose of PRD-92-Ea and predosing with PRD-92-Ea had the same effect in preventing the antiallergic action of a subsequent dose of DSCG. The rhesus monkey (Macaca mulatta) did not exhibit this phenomenon of tachyphylaxis. PRD-92-Ea and DSCG were given i.v. 30 min before and the same dose of 20 mg/kg repeated just before Ascaris suum challenge in the rhesus monkey asthma model with no loss of their expected effectiveness.

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