ASSAY OF THYROID FUNCTION IN DIABETES MELLITUS

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Abstract
Thyroid function was assayed in 25 unselected patients with diabetes mellitus by measuring thyroidal and renal clearance rates of radioiodine (I131). The thyroidal clearance rate of radioiodine was within the normal range in all patients; the renal clearance rate was markedly decreased in patients with intercapillary glomerulosclerosis but was within normal limits in the other diabetic subjects, including 2 with retinopathy without nephropathy. This indicates that thyroidal handling of iodine is normal in all phases of diabetes mellitus and that altered urinary excretion patterns are a reflection of the renal lesion rather than of the underlying systemic disease.