THE SPECIFICITY OF 4-AMINOPTEROYLGLUTAMIC ACID (AMINOPTERIN) FOR LEUKEMIC HEMATOPOIETIC TISSUE
Open Access
- 1 April 1950
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 5 (4) , 358-371
- https://doi.org/10.1182/blood.v5.4.358.358
Abstract
A study of the effect of aminopterin on the hematopoietic tissue of normal mice and mice with transplanted Ak 4 leukemia is reported. At less than lethal doses, aminopterin showed a striking inhibition specificity for neoplastic cell production.Keywords
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