DNA Elements Are Asymmetrically Joined During the Site-Specific Recombination of Kappa Immunoglobulin Genes
- 10 May 1985
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 228 (4700) , 677-685
- https://doi.org/10.1126/science.3158075
Abstract
Immunoglobulin K genes are constructed during lymphocyte differentiation by the joining of two DNA elements, VK and JK, to form both a VKJK coding unit and a reciprocal recombination product. The two products formed in single VK-to-JK joining events can be directly isolated through the use of a retrovirally introduced recombination substrate. The structural analysis of a number of recombinants and the derivation of secondary recombination products define some of the basic features of the mechanism of immunoglobulin gene assembly.Keywords
This publication has 47 references indexed in Scilit:
- A Murine T Cell Receptor Gene Complex: Isolation, Structure and RearrangementImmunological Reviews, 1984
- Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequencesNature, 1984
- DNA sequence studies of simian virus 40 chromosomal excision and integration in rat cellsJournal of Molecular Biology, 1984
- Complete nucleotide sequence of an immunoglobulin VH gene homologue from Caiman, a phylogenetically ancient reptileNature, 1983
- Chance, necessity and antibody gene dynamicsNature, 1983
- Immunoglobulin GenesAnnual Review of Immunology, 1983
- Homothallic switching of yeast mating type cassettes is initiated by a double-stranded cut in the MAT locusCell, 1982
- Variation in the crossover point of kappa immunoglobulin gene V-J recombination: Evidence from a cryptic geneCell, 1980
- Functional and non-functional joining in immunoglobulin light chain genes of a mouse myelomaNature, 1980
- Transposable elementsCell, 1980