SIGNIFICANCE OF SERUM FUCOSE, SIALIC-ACID, HAPTOGLOBIN AND PHOSPHOLIPIDS LEVELS IN THE EVOLUTION AND TREATMENT OF BREAST-CANCER

  • 1 January 1979
    • journal article
    • research article
    • Vol. 49  (2) , 106-112
Abstract
Serum fucose, sialic acid, haptoglobin and phospholipids were determined in 167 women with breast cancer stages I-III, 30 with benign lesions of the breast, 42 women in various physiological states of the mammary gland (pregnancy, early childbed and lactation) and compared with 30 healthy women as control. Serial determinations of these parameters during the radio-surgical treatment were done in 28 patients with breast cancer stage III. Fucose levels were significantly increased and phospholipids were decreased in breast cancer patients but unmodified in the others. Sialic acid and haptoglobin were increased in patients with cancer and in patients in early childbed and with benign affections of the breast. The surveillance of these 4 parameters during radio-surgical treatment of breast cancer evidenced a good correlation between their modified levels and clinical state of the patients. The increase in fucose, sialic acid and haptoglobin and the decrease in the phospholipids were associated with clinical evidence of recurrences and metastases.