EFFECT OF IMIDAZOLE ON IONOPHORE-INDUCED OCULAR HYPERTENSION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 16  (9) , 853-855
Abstract
The effect of i.p. injections of imidazole on the elevation of intraocular pressure [IOP] produced by the topical application of the cation ionophores A23187 2-[3.beta., 9.alpha., 11.beta.-trimethyl)-8-(2-pyrrolecarboxymethyl)-1,7-dioxaspirol[6,6]undecyl-2.beta.-methyl]-5-methylaminobenzoxazole-4-carboxylic acid or X537A lasalocid was studied in rabbits. Pretreatment with 200 mg/kg imidazole completely inhibited the ocular hypertension induced by 1.0% A23187. The elevation of IOP produced by 0.5% X537A was not blocked by pretreatment with imidazole.