HORMONE-RESISTANT PSYCHOGENIC AMENORRHEA

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Abstract
Two cases of hormone-resistant amenorrhea are presented with clinical studies indicating a correlation with psychogenic factors. Studies of estrogen metabolism indicated in both instances an excessively rapid destruction of the administered steroid; this process was unaffected by folic acid, prostigmin or the use of extremely large doses of estrogen and progesterone. In one case, furthermore, the absence of temp. response to progesterone suggested the possibility of abnormal progesterone metabolism as well. Spontaneous cyclic menstruation with normal vaginal smear changes and basal temp. curves reappeared during a time of emotional stability.
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