In VitroandIn VivoObservations on Stored Sickle Trait Red Blood Cells

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Abstract
Blood (500ml) was drawn from each of 6 sickle cell trait donors and stored under conventional blood bank conditions. Interval observations of cell swelling, osmotic fragility, and concentrations of plasma. K and hemoglobin during 28 days of storage were comparable to well-established findings for stored cells that lack the sickle trait. In vivo survival studies revealed normal immediate survival of 21-day stored sickle trait cells, 84% 24-hr. survival of the cells, and a normal disappearance of the surviving cells over the 28 days following transfusion, without evidence of increased splenic sequestration of destroyed cells.