THE ACTIVITY OF HEMOLYSINS IN VIVO

Abstract
The lytic activity of a simple lysin in vivo compared to that in the usual in vitro test system involves 3 factors: the effect of the high conc. of cells and the presence of serum inhibitors in vivo, the fact that lysins are taken up by the tissues in vivo, and the fact that lysins may be constantly supplied in vivo. Taking these factors together, the lytic activity of a lysin in the whole animal is probably only about 1/1000 that observed in the usual in vitro test systems.

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