Partial Primary Structure of the Alpha and Beta Chains of Human Tumor T-Cell Receptors
- 18 January 1985
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 227 (4684) , 311-314
- https://doi.org/10.1126/science.3871253
Abstract
The T-cell receptor for antigen (Ti) was purified from the human tumor cell line HPB-ALL. Amino-terminal sequence analysis of an acid-cleaved peptide of the Ti alpha chain showed that it is highly homologous to a putative murine alpha chain recently described. Amino-terminal sequence analysis of the Ti beta chain revealed that it shares 50 percent homology with the Ti beta chain amino acid sequences from two other human T-cell tumors. Nucleotide sequence analysis of a complementary DNA clone encoding the Ti beta chain from the HPB-MLT cell line showed that this chain represents a second human constant region gene segment and suggested that it arises from direct joining of the variable and joining gene segments without any intervening D region sequences.Keywords
This publication has 22 references indexed in Scilit:
- A third type of murine T-cell receptor geneNature, 1984
- Immunoglobulin-like nature of the α-chain of a human T-cell antigen/MHC receptorNature, 1984
- A third rearranged and expressed gene in a clone of cytotoxic T lymphocytesNature, 1984
- The structure, rearrangement and expression of Dβ gene segments of the murine T-cell antigen receptorNature, 1984
- Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genesNature, 1984
- Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequencesNature, 1984
- The mouse T cell receptor: Comparison of MHC-restricted receptors on two T cell hybridomasCell, 1983
- Somatic generation of antibody diversityNature, 1983
- Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.The Journal of Experimental Medicine, 1983
- An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JHCell, 1980