ANTIBODY RESPONSE OF PATIENTS WITH PNEUMOCOCCIC PNEUMONIA TREATED WITH SULFADIAZINE AND SULFATHIAZOLE

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Abstract
Antibody studies were carried out in 2 groups of patients with pneumococcic pneumonia, 1 treated with sulfadiazine and the other treated with sulfathiazole. The antibody response in these 2 groups of patients was very similar, as judged by the results of the mouse protection, agglutinin and precipitin tests. The results of mouse protection and agglutinin tests in these 2 groups of cases were essentially the same as those previously reported in sulfapyridine-treated cases and in patients who recover without specific serum or chemotherapy. The precipitin test with type-specific polysaccharide is the least sensitive of the 3 tests employed in this study as a measure of antibody production in patients with pneumococcic pneumonia, the mouse-protection test is the most sensitive and the agglutination test is intermediate.