Importance of Body Characteristics in the Excretion of 17-Ketosteroids and 17-Ketogenic Steroids in Obesity

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Abstract
A NUMBER of investigators have reported increased adrenocortical activity among obese persons. These reports have noted the frequency of increased urinary 17-ketogenic steroids,1 2 3 4 increased 17-hydroxycorticosteroids,5 , 6 increased aldosterone7 , 8 and cortisol secretion.9 , 10 Regarding 17-ketosteroid urinary excretion, however, divergent findings have been reported. These steroids in obese subjects have been found to be elevated,3 normal1 , 11 and even diminished.5 In addition, it has been noted in 4 cases of obese children of disparate age that dietary restriction was associated with a decline in 17-ketogenic urinary excretion from initially elevated levels.2 Although some investigators have considered the increased steroid excretion in the obese subject to . . .