Steroidal Influences on Catecholamines

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Abstract
FEW treatments in medicine are based on more tenuous evidence than that used to justify paralysis of the adrenergic nervous system in the contemporary clinical management of "shock." To a large degree such efforts have resulted from preoccupation with one aspect of adrenergic activity, vasoconstriction, and other fundamental aspects of adrenergic responsiveness have been largely ignored. Although alpha-adrenergic receptor blockade with phenoxybenzamine, frequently coupled with high doses of hydrocortisone, has been used to combat vasoconstriction no convincing experimental data exist to justify it; whereas data do support the use of glucocorticoid hormones in shock, there is little information on how . . .