ABSENCE OF BENEFICIAL EFFECTS FROM INJECTIONS OF DESOXYCORTICOSTERONE ACETATE AND OF CORTICAL ADRENAL EXTRACT IN EXPERIMENTAL ANURIA 1

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Abstract
In dogs with anuria following ureteral ligation, the subcut. or intramusc. inj. of desoxycorticosterone acetate (DCA) and of cortical adrenal extract were completely without beneficial effect. No effect on K distribution within the body was detected. Failure to demonstrate such an action of DCA upon potassium distribution in the anuric animal suggests that its effects upon K metabolism in the intact animal are secondary to its renal action. On the basis of present knowledge of its pharmacological action, DCA could only be expected to influence the course of an anuric subject favorably if it were given prior to the establishment of anuria.