Synthesis of Pyranicin and Its Inhibitory Action with Bovine Heart Mitochondrial Complex I
- 6 February 2008
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 10 (5) , 717-720
- https://doi.org/10.1021/ol702902w
Abstract
Total synthesis of pyranicin was achieved using Cl2Pd(CH3CN)2-catalyzed diastereoselective cyclization of the allylic ester as the key step. The inhibitory activity of this compound for mitochondrial NADH-ubiquinone oxidoreductase (complex I) was slightly poorer than that of ordinary mono-THF acetogenins such as cis-solamin.Keywords
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