OBSERVATIONS IN TOTAL BILIARY FISTULA DOGS WITHOUT BILE THERAPY

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Abstract
Four dogs with complete internal biliary fistulae lived for a considerable period of time apparently in good health without any bile therapy. Diet consisted of dog biscuit and milk. Fat-soluble vitamins were administered parenterally. After developing anemia and losing wt. immediately after operation, these animals recovered completely. Studies in some of these dogs showed normal prothrombin time, blood lipids, serum phosphatase, and gastric acidity. No spontaneous hemorrhages, osteoporosis or peptic ulcers developed. Three dogs have died 16, 25, and 42 mos. post-operatively, death resulting from causes other than the bile fistulae. The remaining dog is still alive and appears normal more than 31/2 yrs. after operation. The essentiality of bile for the life of the biliary fistula animals appears to reside largely in its facilitating the absorption of fat-soluble vits.

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