Chemical modification of tylosin. Thioether derivatives of tylosin and demycarosyltylosin.
- 1 January 1984
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 37 (9) , 1007-1015
- https://doi.org/10.7164/antibiotics.37.1007
Abstract
Thioether derivatives of tylosin and demycarosyltylosin were synthesized by Michael-type addition of thiol to C-11 of the enone moiety on the aglycone. Some of tylosin derivatives were effective to macrolide resistant Staphylococcus aureus and their in vivo activities were same or superior than that of tylosin.This publication has 2 references indexed in Scilit:
- Chemical modification of tylosin: Synthesis of amino derivatives at C-20 position of tylosin and demycarosyltylosin.The Journal of Antibiotics, 1983
- Chemical transformation of tylosin,a 16-membered macrolide,and its structure-activity relationship.CHEMICAL & PHARMACEUTICAL BULLETIN, 1982