INFLUENCE OF METHYL-TESTOSTERONE UPON THE 'ENDOCRINE KIDNEY'

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Abstract
Hypertension and its morph. components produced in rats by the endocrine kidney technique remain uninfluenced by methyl-testosterone or changes in the dietary NaCl. The histological structure of the endocrine kidney is, however, affected by methyl-testosterone. There is hyper- plasia and hypertrophy of the spiral segment of the proximal convoluted tubules and the loss of eosinophilic granules in this segment is also prevented. It is concluded that kidney-growth stimulation is due to a direct trophic action and not secondary to metabolic changes necessitating increased renal excretory work.