Multipotentiality of yolk‐sac carcinoma cell clones

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Abstract
Yolk‐sac carcinoma (YSCa) clones were isolated by manual cloning under visual control. By morphology, immunohistology and histochemistry the clones were shown to differentiate in vitro into visceral and parietal yolk‐sac cells and in vivo into visceral and parietal yolk‐sac cells, trophoblast and mesenchyme. Trophoblast and mesenchyme were only recorded in rat YSCa derived from displaced yolk sac but not in embryoderived YSCA. Hence YSCa cells displaying a visceral and parietal yolk‐sac pattern as well as the trophoblastic and the mesenchymal structures should have a common cell ancestor.