Effect of Beta-Aminopropionitrile and Cholesterol on Lipids and Aortic S35-Sulphated Mucopolysaccharides in Cockerels

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Abstract
Beta-aminopropionitrile (BAPN) alone, or combined with cholesterol was added to diet of cockerels for 4 weeks. The concentration of 0.0259: of BAPN and 2% of cholesterol in diet, was used in this study. Normal diet or cholesterol rich diet was fed to control birds. BAPN feeding resulted in deformities of extremities and frequent death from aortic rupture. These changes were not influenced by addition of cholesterol to the diet. BAPN had no effect on lipid content in serum, liver or aorta. Alteration in lipid pattern was obtained only with cholesterol rich diet. Parallel to increase of lipids in tissues there was a significant rise of S35 uptake by sulphated mucopolysaccharides of the aorta in cholesterol fed cockerels. BAPN did not alter the metabolism of lipids and mucopolysaccharides under the described experimental conditions.