A MALDI-chip integrated system with a monitoring window
- 16 February 2005
- journal article
- Published by Royal Society of Chemistry (RSC) in Lab on a Chip
- Vol. 5 (4) , 378-381
- https://doi.org/10.1039/b418986h
Abstract
The integration of a monitoring port along the microfluidic path of a MALDI-chip integrated device is described. Optimization of the microreactor design allows longer reaction and measuring times. The Schiff base reaction between 4-tert-butylaniline (1) and 4-tert-butylbenzaldehyde (2) in ethanol was carried out on-chip in the MALDI ionization chamber and the formed imine 3 was detected in real time, demonstrating the feasibility of the “monitoring window” approach. This preliminary result opens the way to on-chip kinetic studies by MALDI-MS, by opening multiple monitoring windows along the microchannel.Keywords
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