Atropine vs Glycopyrrolate During Reversal of Pancuronium Block in Patients Anaesthetized with Halothane

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Abstract
Atropine 0.015 mg/kg and glycopyrrolate 0.0075 mg/kg were compared as antimuscarinic agents during reversal of pancuronium block with neostigmine 0.03 mg/kg in 30 patients anesthetized with thiopental-N2O-halothane and undergoing minor surgery. In patients treated with atropine-neostigmine, the frequencies of bradycardia and junctional rhythm were relatively high and about the same as those reported previously in patients anesthetized with thiopental-N2O-fentanyl. Glycopyrrolate seemed to have advantages over atropine during reversal of pancuronium block; the incidences of bradycardia and junctional rhythm were significantly less in patients treated with glycopyrrolate. Recovery from anesthesia, as assessed by the awakening after discontinuation of N2O and halothane administration, and the incidence of postoperative nausea and vomiting, were not significantly different between the atropine and glycopyrrolate groups.