EFFECTS OF THE HYPERGLYCEMIC-GLYCOGENOLYTIC FACTOR (HGF) FOUND IN INSULIN PREPARATIONS

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Abstract
Studies on normal and bilaterally adrenalectomized adult rabbits reveal that commercial insulin prepns., including novo insulin, contain a hyperglycemic-glycogenolytic factor (HGF), the concn. varying with different brands and/or lots manufactured. The HGF causes glycogenolysis of liver glyco-gen to glucose. This effect is most marked when the HGF reaches the liver via the shortest route (intraven.). The protein HGF is inactivated or broken down when given subcut. The degree of hyperglycemia bears no consistent relationship to the dose of HGF, is enhanced by anesthesia, and is abolished or greatly reduced by fasting. In addition to adequate liver glycogen, it is presumed that some adrenal gland (medulla and/or cortex) factor is necessary for the hyperglycemia. The physiol. significance of the HGF is discussed, with the conclusion that there has been no clearcut evidence that the HGF is a hormone and/or that it is secreted by the alpha-cell or the argentophil cell of the pancreas.
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