Probing the Folate-binding Site of Human Thymidylate Synthase by Site-directed Mutagenesis
Open Access
- 1 November 1998
- journal article
- research article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 273 (47) , 31209-31214
- https://doi.org/10.1074/jbc.273.47.31209
Abstract
No abstract availableKeywords
This publication has 42 references indexed in Scilit:
- The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 å resolution: implications for a new mode of inhibitionStructure, 1996
- Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active siteBiochemistry, 1995
- Enhancement of thymidylate synthase inhibitionCurrent Opinion in Oncology, 1993
- Refined Structures of Substrate-bound and Phosphate-bound Thymidylate Synthase from Lactobacillus caseiJournal of Molecular Biology, 1993
- Structure-Based Discovery of Inhibitors of Thymidylate SynthaseScience, 1993
- Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysisJournal of Medicinal Chemistry, 1992
- Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2′-deoxyuridylate and 5,10-methylenetetrahydrofolateJournal of Molecular Biology, 1990
- Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2′-deoxyuridylate and 10-propargyl-5,8-dideazafolateJournal of Molecular Biology, 1990
- A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in micePublished by Elsevier ,1981
- Factors affecting substrate binding in Lactobacillus casei thymidylate synthetase as studied by equilibrium dialysisBiochemistry, 1976