Biodistribution of64Cu in rats after topical application of two lipophilic anti-inflammatory Cu(II) formulations
- 1 March 1984
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 14 (2) , 291-295
- https://doi.org/10.1007/bf01966655
Abstract
64Cu(II) is extensively absorbed and excreted, mainly in the faeces, when applied to the skin of rats as complexes with (a) salicylate in ethanol with dimethylsulphoxide and glycerol or (b) phenylbutazone in dimethyl sulphoxide and glycerol, previously found to be anti-inflammatory.64Cu distribution paralleled that observed after administering aqueous64Cu-salicylate i.m. It is concluded that copper(II) can pass rapidly through the dermal barriers when applied with an appropriate cupriphore and presented in a medium with low water content.This publication has 7 references indexed in Scilit:
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