Suppression of Activity of the Adrenal Cortex by Dexamethasone in Cushing's Syndrome

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Abstract
Suppression of the 17-hydroxycorticolds in the urine to 2.5 mg/24 hr. during the second day of the ingestion of dexamethasone, 0.5 mg every 6 hr., was thought to be strong evidence against the diagnosis of Cushing''s syndrome. Nonetheless, adrenalectomy was advised because of the clinical features and other suggestive data. The diagnosis was confirmed by the finding of enlarged glands and the subsequent course.