Endogenous Alkaloids in Man, VII1): 1‐Trichloromethyl‐1,2,3,4‐tetrahydro‐β‐carboline ‐ A Potential Chloral‐Derived Indol Alkaloid in Man
- 1 January 1990
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 323 (9) , 567-569
- https://doi.org/10.1002/ardp.19903230903
Abstract
The trichloromethyl tetrahydro-β-carboline 5, an imaginable, chloral-derived mammalian indol “alkaloid”, was prepared in high yields and was shown to be formed even under mild, physiological conditions, in aqueous medium. For its detection in low concentrations, a chromatographic procedure was elaborated. Furthermore, its potential metabolite 8 was synthesized for the first time.This publication has 17 references indexed in Scilit:
- First Synthesis of 1-Trichloromethyl-6,7-dihydroxytetrahydroisoquinoline — An Imaginable Chloral-derived Mammalian AlkaloidHETEROCYCLES, 1987
- New Methods for the Preparation 2-Formyl-1,2,3,4-tetrahydroisoquinolinesvia N-Formyliminium IonsSynthesis, 1987
- Endogene Alkaloide im SäugerorganismusNachrichten aus Chemie, Technik und Laboratorium, 1986
- A new asymmetric route to (+)-vincamineJournal of the Chemical Society, Chemical Communications, 1986
- The Total Synthesis of (—)-DihydrocorynantheolHETEROCYCLES, 1985
- Excretion of tetrahydroharmane and harmane into the urine of man and rat after a load with ethanolFEBS Letters, 1980
- The Formation of Alkaloids in Mammalian TissuesHETEROCYCLES, 1975
- Biogenetic-type total synthesis of ajmalineJournal of the American Chemical Society, 1970
- The Synthesis of Derivatives of β-Carboline. II. Syntheses from dl-Tryptophan and Aldehydes1Journal of the American Chemical Society, 1948
- Über die Bildung von Isochinolin‐derivaten durch Einwirkung von Methylal auf Phenyl‐äthylamin, Phenyl‐alanin und TyrosinEuropean Journal of Inorganic Chemistry, 1911