Water and NaCl intake after furosemide treatment in sheep (Ovis aires).

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Abstract
I.v. infusion of the natriuretic drug furosemide in sheep led to the excretion of large quantities of hypotonic urine. The sheep consumed more water than was needed simply to restore osmotic equilibrium. The stimulus for the additional intake was presumably hypovolemia resulting from the loss of Na in urine. Despite the natriuresis, in only 2 of 15 experiments did sheep drink significant amounts of 0.5 M NaCl solution during the first 10 h after the onset of furosemide treatment, and hemoconcentration and arterial hypotension were evident during this time. By 24 h, the saline consumption in all but 3 experiments increased and compensated adequately (together with the water intakes) for the furosemide-induced loss of Na-rich fluid in urine. Following acute hypovolemia in sheep, as in rats, the onset of Na appetite is apparently delayed relative to the appearance of thirst.

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