Comparison of iv and ia infusion of vasoactive agents on dog forelimb blood flow

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Abstract
A comparison of the effects of intrabrachial and intravenous administration of vasoactive agents on forelimb blood flow was made in the dog. The agents were administered by infusion at a variety of rates; pressures and flows were measured after they became stable. Epinephrine and levarterenol reduced total forelimb blood flow by both routes of administration, less by the intravenous route, while angiotensin decreased flow only during intrabrachial infusion. Acetylcholine, histamine, and brady-kinin had relatively minor effects on total flow during intravenous infusion but greatly enhanced flow during intrabrachial infusion. Serotonin [5 hydroxytryptamine] affected total flow minimally by either route of administration. Changes in brachial (muscle) and cephalic (skin) venous outflows were in the same direction as total flow except during intrabrachial infusion of serotonin where cephalic flow fell and brachial flow rose. Acetylcholine, bradykinin, and histamine had little effect on filtration during intravenous infusion, but enhanced filtration during intrabrachila infusion. Thus the responses of flow and filtration to the agents depended upon the route of admin-i stration.

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