A note on the disturbance of the haemoglobin metabolism of the rat by sulphanilamide

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Abstract
After treatment with sulfanilamide, rats were observed to show increased excretion of urobilins. The reported increase in urinary excretion of coproporphyrin after such treatments was, however, not found and it is concluded that such a porphy-rinuria does not derive from an abnormal breakdown of the prosthetic group of hemoglobin, but in some other way. Dietary deficiencies are thought to be responsible for the failure to observe this phenomenon in the author''s expts. The increase in fecal excretion of the urobilins was not noticed in all the rats treated with the drug, but in most there was a marked increase in the ratio of mesobilene-b to tetrahydromesobilene-b. The latter phenomenon is probably due to the influence of the drug on the flora of the intestines.