MYOCARDIAL IMAGING AND METABOLIC STUDIES WITH [17-I-123]IODOHEPTADECANOIC ACID

  • 1 January 1980
    • journal article
    • research article
    • Vol. 21  (11) , 1043-1050
Abstract
After i.v. administration of the stearic acid analogue, [17-123I]iodoheptadecanoic acid (I-123 HA), myocardial metabolism was studied in 10 normal individuals, 8 patients with coronary artery disease and 3 patients with congestive heart failure. High-quality images were obtained in sequential scintigraphy of I-123 metabolically bound in myocardial tissue. Infarcted zones and ischemic regions are indicated by reduced tracer uptake. Iodine-123 in the blood pool and interstitial space consists mainly of radioiodide that is liberated by fatty-acid metabolism and was corrected for. Using the proposed correction, not only are the images improved but the uptake and elimination of the I-123 in the myocardial cells can be followed. The average disappearance half-time of I-123 HA from the myocardium of normal persons was 24 .+-. 4.7 min. In patients with coronary artery disease, significant differences between myocardial regions were observed.