HISTOLOGICAL CHANGES AND BLOOD SUGAR FLUCTUATIONS IN THE MARINE TELEOST COTTUS SCORPIUS FOLLOWING ADMINISTRATION OF THE SULFHYDRYL INHIBITOR IODOACETIC ACID

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Abstract
Iodoacetic acid (IAA) administered to Cottus scorpius in single or repeated intramuscular injections slightly less than the L. D. 50 and up to sublethal dosages evoked a moderate hyperglycaemia in about 1/3 of the animals. There were practically no concomitant morphological changes in the pancreatic islet tissue. In the kidneys and the liver, histological changes were found such as a diffuse and patchy degeneration of the renal tubules and small liver necroses. The myocardium and brain were unaffected. The hyperglycaemia found was provisionally considered not to be of pancreatic origin and IAA therefore regarded as a nondiabetogenic sulfhydryl inhibitor.