Effects of adenosine 3‘,5’‐monophosphate on renal function in the rabbit

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Abstract
1 Intravenous injections of adenosine 3′,5′-monophosphate (cyclic-AMP) were given to five conscious, diuretic rabbits, and the effects on urinary flow and composition were compared with those of intravenous injections of vasopressin given to the same animals. 2 Cyclic-AMP produced antidiuresis with increases in urinary osmolality and in the urinary concentrations of creatinine, urea and usually of sodium. 3 The fractional reabsorption of urea from renal tubular fluid increased during cyclic-AMP induced antidiuresis. 4 The effects of cyclic-AMP thus closely resembled those of vasopressin and are consistent with the view that cyclic-AMP mediates the action of this hormone.