Tissue-specific expression of three distinct types of rabbit protein kinase C

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Abstract
We examined the structure of protein kinase C in an attempt to understand the molecular events connecting protein kinase C activation with the cellular response 1–3. Rabbit complementary DNA clones coding for three distinct types of protein kinase C, named α, β and γ, have been identified and sequenced. The deduced amino acid sequence for α, β and γ (673, 671 and 672 amino acids, respectively) are closely related. Kinases α and β share an identical TV-terminal sequence of 621 amino acid residues and their messenger RNAs arise from a single gene. The C-terminal halves of α, β and γ are protein kinase domains and are highly homologous to other protein kinases. The mRNAs for α, β and γ are expressed in various tissues with strikingly different tissue specificities. The one for γ is found ubiquitously among various tissues, while those for α and β predominate in the brain.