Epidemic Coxsackie Virus Infection with Mixed Clinical Manifestations

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Abstract
During the summer and fall of 1960 43 patients with acute, febrile illnesses were studied for evidence of virus infection. 10 distinct clinical syndromes (fever of undetermined origin, herpangina, abdominal pain, pleurodynia, orchitis, myocarditis, pericarditis, meningitis or encephalitis, undifferentiated rash and diarrhea) as well as asymptomatic infection were observed. 28 persons had associated group B Coxsackie virus infections with serotypes 2,3,4 and 5; there was one ECHO virus type 4 infection and in 14 patients the etiology remained undetermined. It was concluded that dissemination of a number of closely related viruses within a community may produce epidemics of heterogeneous symptomatology, a situation impossible to recognize on clinical grounds alone.

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