rasH mutants deficient in GTP binding.
Open Access
- 1 September 1986
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 6 (9) , 3291-3294
- https://doi.org/10.1128/mcb.6.9.3291
Abstract
Single amino acid substitutions were introduced into a region of the rasH protein (residues 116, 117, and 119) homologous to a variety of diverse GTP-binding proteins. Each of the mutant p21 proteins displayed a significant reduction (10- to 5,000-fold) in GTP binding affinity. Activated rasH proteins deficient in GTP binding were unaltered in their ability to morphologically transform NIH 3T3 cells.This publication has 45 references indexed in Scilit:
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